Dresden Files. We played in a nice beach town that was close to a Nuclear Power Plant that was also a secret research center because, it's Dresden, you're naive to think if the local McDonalds isn't selling Harry Human flesh or some weird shit. Anyway, campaign was like Buffy until one chick went full Carrie and... The campaign exploded with the White Council joining forces with the Vampires to somehow keep the Masquerade from falling apart as a detachment of Marines arrived to contain the disaster. It ended with CIA black ops trying to cover the whole incident up by purging trapped Marines. This ended with a free for all between the Red Court, the CIA, the Marines, the few surviving civilians, and the White Council.
Eventually genetically engineered Supersoldiers were activated and started killing everyone before Harry set off a mininuke and... Killed the party. Goddamn, that a fun game.