My Gods are massive in scope, distant to the affairs of man as they got bigger shit to fry like slinging galaxies and aligning constellations. The great evils my players face are mere microscopic remnants of greater terrors lurking deep in the void. Yes, I copied Samurai Jack. And no, I have no regrets. Mortals can become deities if they become mythic tiered immortals but that's extremely rare and only happens during the darkest of times when the world nearly gets destroyed.
When it comes to deities, I think the worst thing you can do is the Jim Butcher treatment with them as yet another pack of bland superheroes that can be soloed by a single fucking (his literal word of god) Predator Drone which makes me wonder why ancient people even bothered worshiping them in the first place.