First of all, kill yourself.
Secondly, think for a long minute about what it means to draw something big and in the middle of a page, and also what it means to draw something small and in the side of the page. What could the author intention have been by doing that? Why bring more focus to certain panels?
This is all pretty basic stuff that even the more challeged people can get, which is why i think you will be able to understand it too anon.