You're saying this as if this isn't exactly what most of the LoV has been about from the start.
Toga's quirk is morbid and Twice's quirk drove him insane. Shiggy lost his faith in society due to the failure of heroes to help him in a time of need, as well as having an inherently destructive quirk. Even Spinner has a very prominent mutation type quirk and appears to be a shut-in, and Magne is trans. Kurogiri, Dabi, and Mr. Compress are the only ones with no obvious connection to the theme of society creating its villains.
Okay, this is sounding a little smug, but I've been pushing this since before we found out about even Twice's backstory and vindication is nice; in any case the point is that yeah, all it would have taken is a little care to avert this, and that's exactly the point.